Patagonia may be off the beaten track, and you may have to take some gravel roads to get there, but it doesn't have to be complicated!
Most flights transfer travelers from Santiago, Chile Buenos Aires south toward Patagonia.
Chile's Punta Arenas serves as the primary gateway into Chilean Patagonia.
Argentina's El Calafate serves as the primary gateway into Argentinian Patagonia.
Travelers can start from Buenos Aires, Santiago, Cordoba and Mendoze down south toward Patagonian destinations south. However, it's a widespread country, so this isn't the most efficient way to travel.
The Navimag ferry runs between Puerto Natales and Puerto Montt, with some routes stopping over at Laguna San Rafael, Puerto Chacabuco and Chiloé Island.